Ученые тестируют новое лекарство от рака кишечника. 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22.12.2023
20 5 minutes read

Каждый год от рака погибает порядка 10 миллионов человек во всем мире. И хотя многие виды онкологии излечимы при своевременной постановке диагноза и терапии, универсального лекарства от этой болезни нет. Все потому, что рак представляет собой порядка 200 различных заболеваний, поражающих разные органы и системы организма. Более того, каждый распространенный тип онкологии имеет множество подтипов, каждый из которых выглядит и ведет себя по-разному. А одна из причин, по которой рак так трудно поддается лечению, заключается в индивидуальных различиях каждого конкретного человека – в конечном итоге раковые опухоли возникают из клеток нашего организма, а мы, как известно, сильно отличаемся друг от друга. И все же, некоторые виды рака встречаются чаще других и лучше поддаются лечению. Так, в ходе последнего этапа клинических испытаний на людях многообещающий результат в лечении специфической формы рака кишечника показал препарат под названием диварасиб. Рассказываем что известно о новом лекарстве.

Ученые тестируют новое лекарство от рака кишечника. 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Результаты ранних клинических испытаний нового препарата от рака кишечника оказались обнадеживающими. Что это за лекарство?

Содержание

  • 1 Рак кишечника – что нужно знать?
  • 2 Симптомы и факторы риска
  • 3 Диварасиб – новый препарат от рака
  • 4 Профилактика колоректального рака

Рак кишечника – что нужно знать?

Рак толстой кишки – это опасная для жизни опухоль, возникающая в результате роста клеток в части толстой, которая является последней частью пищеварительной системы. Такие опухоли являются злокачественными, поскольку раковые клетки могут прорастать в окружающие ткани, распространяясь по телу и давая метастазы – дополнительные очаги заболевания.

Отметим, что рак толстой кишки иногда называют колоректальным раком. Этот термин объединяет рак толстой кишки и рак прямой кишки, который начинается в прямой кишке. Как правило заболевание встречается у пожилых людей, однако болезнь может возникнуть в любом возрасте. Обычно все начинается с небольшого скопления клеток, называемых полипами, которые образуются внутри толстой кишки. Сами по себе полипы злокачественными не являются, но некоторые из них со временем могут превратиться в рак.

Ученые тестируют новое лекарство от рака кишечника. 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При колоректальном раке боль появляется при вовлечении тканей, окружающих прямую кишку.

Читайте также: Новый взгляд на онкологические заболевания: что такое паразитарная теория рака?

Полипы часто не вызывают симптомов из-за чего врачи рекомендуют регулярно проходить обследования для их выявления в толстой кишке. Обнаружение и удаление полипов помогает предотвратить развитие онкологии. В случаях, когда заболевание не удалось обнаружить на ранней стадии, применяются многие методы лечения, включая хирургическое вмешательство, лучевую терапию, химиотерапию и лекарственные препараты.

Симптомы и факторы риска

Как говорилось выше, многие люди не подозревают о наличии заболевания из-за отсутствия каких-либо симптомов. Однако, когда они появляются, то зависят от размера опухоли и ее месторасположения в толстой кишке. Симптомы колоректального рака могут включать диарею или запор, кровотечение, спазмы, боль и дискомфорт в области живота, слабость и потерю веса.

На сегодняшний день врачи не могут точно сказать что вызывает большинство случаев рака толстой кишки. Как правило он (как и другие виды онкологических заболеваний) развивается в результате накопления мутаций (изменений) в ДНК из-за чего клетки начинают быстро размножаться.

Ученые тестируют новое лекарство от рака кишечника. 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Это опасное заболевание на ранних стадиях проявляется бессимптомно. Признаки рака толстой кишки проявляются уже на 3 и 4 стадии.

Еще больше интересных статей о последних открытиях в области медицины и высоких технологий читайте на нашем канале в Яндекс.Дзен – там регулярно выходят статьи, которых нет на сайте!

Так как происходящие изменения позволяют клеткам жить (в то время как здоровые клетки умирают в рамках естественного жизненного цикла), в конечном итоге их образуется слишком много – именно эту «излишнюю» массу и называют опухолью. По мере развития болезни раковые клетки могут проникать в здоровые ткани, разрушая их.

Исследователи выделяют множество факторов, способных увеличить риск возникновения колоректального рака, среди которых пожилой возраст (старше 50 лет), воспалительные заболевания кишечника, наличие родственников с раком толстой или прямой кишки. Специалисты также рекомендую обратить внимание на питание, так как колоректальный рак может быть связан с низким употреблением клетчатки и высоким потреблением жиров.

Ученые тестируют новое лекарство от рака кишечника. 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В случае проблем с пищеварением и дискомфортом в животе необходимо обратиться к врачу

Более того, одним из факторов риска является малоподвижный образ жизни – люди, которые нерегулярно или вообще не занимаются спортом, более склонны к развитию рака толстой кишки. То же самое касается людей с ожирением и диабетом.

Читайте также: Один из «бесполезных» органов человека быть защитником от рака — вот доказательство

Диварасиб – новый препарат от рака

В ходе последнего этапа ранних испытаний на людях препарат под названием диварасиб показал обнадеживающие результаты в лечении колоректального рака, превзойдя все существующие альтернативы. В работе, опубликованной в журнале Nature Medicine, исследователи из онкологического центра Питера Маккаллума в Австралии обнаружили, что при сочетании диварасиба с другим препаратом под названием цетуксимаб у 62% пациентов с опухолями, наблюдался положительный результат – то есть их опухоли были либо полностью уничтожены либо значительно уменьшились в размерах.

Предыдущие исследования показали, что даже при применении только одного препарата результат также впечатляющий – диварасиб в 20 раз эффективнее других методов лечения, – отмечает издание NewAtlas. И все же, несмотря на многообещающие результаты, это препарат узкого применения, который будет эффективен лишь для небольшой части больных раком толстой кишки.

Ученые тестируют новое лекарство от рака кишечника. 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Лекарство от рака кишечника показало многообещающие результаты на людях

Не пропустите: Ученые создали универсальный препарат от рака?

Мутация, KRAS G12C, влияет на белок, который контролирует деление клеток, и, по словам исследователей, встречается только в четырех процентах случаев рака толстой кишки или прямой кишки (колоректального рака). Однако, поскольку рак KRAS G12C обычно диагностируется и имеет такой неблагоприятный прогноз, врачи могли бы быстро выявить пациентов, которым диварасиб принесет пользу, обеспечивая немедленное — и потенциально спасающее жизни – облегчение.

Медиана выживаемости без прогрессирования у пациентов в исследовании» — количество времени во время или после лечения, в течение которого они могли жить без ухудшения состояния рака, — «составила чуть более восьми месяцев, и лечение хорошо переносилось с управляемыми побочными эффектами, — сказал ведущий автор исследования Джайеш Десаи, доктор медицинских наук.

Отметим, что существующие методы лечения рака кишечника, вызванного мутацией гена KRAS G12C, такие как химиотерапия и иммунотерапия, дают очень скромные результаты. Их главный недостаток заключается в том, что они неселективны и воздействуют на весь организм, а не на смертельные опухоли – проблему, которую диварасиб, по—видимому, обещает обойти. Авторы работы надеятся, что комбинация диварасиба с цетуксимабом приведет к улучшению результатов лечения пациентов с колоректальным раком.

Профилактика колоректального рака

Ну а пока новый препарат находится на стадии клинических испытаний, напомним, что наилучшим способом оставаться здоровым является своевременное обращение к врачу и прохождение необходимых обследований.
Так, врачи рекомендуют людям со средним риском развития рака толстой кишки рассмотреть возможность начала скрининга примерно в возрасте 45 лет. Но людям с повышенным риском следует подумать о начале скрининга раньше.

Значительно снизить риск развития колорекательного рака является ведение здорового образа жизни. Для этого следует есть разнообразные фрукты, овощи и цельнозерновые продукты, которые содержат витамины, минералы, клетчатку и антиоксиданты, способные помочь предотвратить рак.

Более того, правильное и здоровjе питание, наряду с регулярными занятиями спортом поможет сбросить лишние килограммы и чувствовать себя хорошо.

Ученые тестируют новое лекарство от рака кишечника. 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Существует несколько различных тестов, которые используются для скрининга рака толстой кишки.

От алкоголя лучше всего отказаться, либо употреблять его в умеренных количествах, ограничив количество выпиваемого не более чем одним напитком в день для женщин и двумя для мужчин. Ну и от курения, разумеется, следует отказаться. А вот о том, как это сделать читайте в материале моего коллеги Андрея Жукова. Будьте здоровы!

Источник

22.12.2023
20 5 minutes read
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25.09.2023

Где больше всего животных: над или под поверхностью Земли — Hi-News.ru»>/**/ article{display:block}body{font-size:14px;line-height:1}ol,ul{list-style:none;padding:0;margin:0}html,body{font:400 -apple-system,BlinkMacSystemFont,sans-serif}html,body,div,span,iframe,h1,p,a,img,ins,strong,b,form,article,time{margin:0;padding:0;border:0;font-size:100%;-webkit-text-size-adjust:100%;font-family:-apple-system,BlinkMacSystemFont,sans-serif;vertical-align:baseline;-webkit-font-smoothing:antialiased}body{font-size:14px;line-height:1;min-width:1124px}ol,ul{list-style:none;padding:0;margin:0}b,strong{font-weight:700}img{overflow:hidden;height:auto;max-width:100%;font:400 10px -apple-system,BlinkMacSystemFont,sans-serif}p{color:#000;margin-bottom:15px;font:400 20px/1.5 -apple-system,BlinkMacSystemFont,sans-serif}h1{color:#000;margin:0 0 28px 0;font:700 54px/1 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17.08.2023

Древнеегипетский папирус содержит подробное описание исчезнувших ядовитых змей — Hi-News.ru»>/**/ article{display:block}body{font-size:14px;line-height:1}ol,ul{list-style:none;padding:0;margin:0}html,body{font:400 -apple-system,BlinkMacSystemFont,sans-serif}html,body,div,span,iframe,h1,p,a,img,ins,strong,b,form,article,time{margin:0;padding:0;border:0;font-size:100%;-webkit-text-size-adjust:100%;font-family:-apple-system,BlinkMacSystemFont,sans-serif;vertical-align:baseline;-webkit-font-smoothing:antialiased}body{font-size:14px;line-height:1;min-width:1124px}ol,ul{list-style:none;padding:0;margin:0}b,strong{font-weight:700}img{overflow:hidden;height:auto;max-width:100%;font:400 10px -apple-system,BlinkMacSystemFont,sans-serif}p{color:#000;margin-bottom:15px;font:400 20px/1.5 -apple-system,BlinkMacSystemFont,sans-serif}h1{color:#000;margin:0 0 28px 0;font:700 54px/1 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24.10.2023

Туристы в испуге возвращают вещи, взятые в Помпеях — считается, что они прокляты — Hi-News.ru»>/**/ article{display:block}body{font-size:14px;line-height:1}ol,ul{list-style:none;padding:0;margin:0}html,body{font:400 -apple-system,BlinkMacSystemFont,sans-serif}html,body,div,span,iframe,h1,p,a,img,ins,strong,b,form,article,time{margin:0;padding:0;border:0;font-size:100%;-webkit-text-size-adjust:100%;font-family:-apple-system,BlinkMacSystemFont,sans-serif;vertical-align:baseline;-webkit-font-smoothing:antialiased}body{font-size:14px;line-height:1;min-width:1124px}ol,ul{list-style:none;padding:0;margin:0}b,strong{font-weight:700}img{overflow:hidden;height:auto;max-width:100%;font:400 10px -apple-system,BlinkMacSystemFont,sans-serif}p{color:#000;margin-bottom:15px;font:400 20px/1.5 -apple-system,BlinkMacSystemFont,sans-serif}h1{color:#000;margin:0 0 28px 0;font:700 54px/1 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21.01.2024
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